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一種針對(duì)多粘菌素耐藥菌特異性治療候選輔助藥物

成果領(lǐng)域: 現(xiàn)代農(nóng)業(yè)

推廣方式:

成果歸屬企業(yè): 吉林大學(xué)汽車動(dòng)物醫(yī)學(xué)學(xué)院鄧旭明教授科研團(tuán)隊(duì)

成果鑒定時(shí)間:

成果介紹

針對(duì)全世界范圍廣泛流行的mcr-1及攜帶菌的多粘菌素耐藥性問(wèn)題，進(jìn)行長(zhǎng)期和大量的天然化合物抑制劑篩選，發(fā)現(xiàn)以MR1033為代表的多種化合物可恢復(fù)多粘菌素對(duì)不同來(lái)源攜帶mcr-1大腸桿菌的敏感性，協(xié)同作用明顯（FIC index=O.156-0.188）。在小鼠腹腔感染和肺部感染模型中顯著提高多粘菌素B的治療率。

成果應(yīng)用案例介紹

聯(lián)系方式

電話/微信: 13822630888

相關(guān)成果

免責(zé)聲明 / 網(wǎng)站地圖 / 平臺(tái)簡(jiǎn)介 / 友情鏈接

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基本文件流程錯(cuò)誤 SQL 調(diào)試

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[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000010s ]
[ CACHE ] INIT File
[ BEHAVIOR ] Run \addons\briefurl\Briefurl @app_init [ RunTime:0.001263s ]
[ BEHAVIOR ] Run \addons\fastflow\Fastflow @app_init [ RunTime:0.000024s ]
[ BEHAVIOR ] Run \addons\notice\Notice @app_init [ RunTime:0.000244s ]
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[ BEHAVIOR ] Run \addons\treaty\Treaty @app_init [ RunTime:0.000030s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @app_init [ RunTime:0.000015s ]
[ BEHAVIOR ] Run Closure @app_init [ RunTime:0.000033s ]
[ BEHAVIOR ] Run app\common\behavior\Common @app_init [ RunTime:0.000312s ]
[ LANG ] /www/wwwroot/open.juabc.com/thinkphp/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @app_dispatch [ RunTime:0.000013s ]
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[ PARAM ] array ( 'ids' => '4551', )
[ LANG ] /www/wwwroot/open.juabc.com/public/../application/index/lang/zh-cn.php
[ BEHAVIOR ] Run app\common\behavior\Common @module_init [ RunTime:0.000678s ]
[ BEHAVIOR ] Run \addons\upyun\Upyun @module_init [ RunTime:0.000137s ]
[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @module_init [ RunTime:0.000025s ]
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[ BEHAVIOR ] Run \addons\notice\Notice @config_init [ RunTime:0.000021s ]
[ DB ] INIT mysql
[ BEHAVIOR ] Run \addons\csmtable\Csmtable @action_begin [ RunTime:0.000040s ]
[ RUN ] app\index\controller\Results->views[ /www/wwwroot/open.juabc.com/application/index/controller/Results.php ]
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[ BEHAVIOR ] Run \addons\wxfollowlogin\Wxfollowlogin @view_filter [ RunTime:0.000032s ]

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